about us

ImmunoCellular Therapeutics, Ltd.  is a Los Angeles-based clinical-stage company that is developing immune-based therapies for the treatment of brain and other cancers. The phase 3 registrational trial of lead product candidate, ICT-107, a dendritic cell-based immunotherapy targeting multiple tumor-associated antigens on glioblastoma stem cells, is open for patient screening. ImmunoCellular's pipeline also includes: ICT-121, a dendritic cell immunotherapy targeting the CD133 antigen on stem cells in recurrent glioblastoma; ICT-140, a dendritic cell immunotherapy targeting antigens on ovarian cancer stem cells; and the Stem-to-T-cell research program which engineers the patient's hematopoietic stem cells to generate antigen-specific cancer-killing T cells.

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ICT-107 is a dendritic cell-based immunotherapy targeting multiple tumor-associated antigens on glioblastoma stem cells. A phase 3 registrational trial in patients with newly diagnosed glioblastoma, the most common and lethal form of brain cancer, is open for patient screening. The phase 3 registrational trial is designed as a randomized, double-blind, placebo-controlled study of over 400 HLA-A2+ subjects, which will be conducted at about 120 sites in the US, Canada and the EU. The primary endpoint in the trial is overall survival, which the FDA and EU regulators have stated is the appropriate endpoint for registrational clinical studies in glioblastoma. Secondary endpoints include progression-free survival and safety, as well as overall survival in the two pre-specified MGMT subgroups.

ICT-121 is a DC immunotherapeutic that targets CD133, an antigen commonly associated with cancer stem cells (CSCs). We are conducting a 20-patient Phase 1 clinical trial in patients with recurrent glioblastoma.

ICT-140 is a DC immunotherapeutic that targets seven different antigens associated with ovarian cancer, including those expressed by CSCs. A phase 2 trial is awaiting a partnership or other financing to proceed.

ImmunoCellular’s goal is to become an industry-leading, independent, commercial-stage cancer immunotherapy company. We have a development pipeline of therapeutically important, commercially attractive product candidates, and a highly productive, proprietary cancer immunotherapy platform. These assets have the potential to transform the treatment of cancer, benefit patients and create value for our stakeholders.

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