ImmunoCellular Therapeutics to Present at Cowen and Company's 32nd Annual Health Care Conference
March 12, 2012
LOS ANGELES, CA – ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular" or the "Company") (OTCBB: IMUC)today announced that its proprietary method for manufacturing ICT-107, its lead dendritic cell (DC) based vaccine for the treatment of glioblastoma multiforme (GBM), has demonstrated meaningfully enhanced efficiency, consistency and convenience, compared to other methods for producing DC-based immunotherapies.
Developed in collaboration with the Company’s partners, the manufacturing method employs a closed-bag system designed to produce highly potent DCs from white blood cells (WBCs) collected from patients, and for subsequently cryopreserving the DCs for future vaccine treatments. The process has also been optimized to produce high levels of certain cytokines that play a key role in initiating immune response.
Analysis of manufacturing data indicates that this process can produce up to 30 vials of ICT-107 product and 30 vials of placebo (DCs without tumor-specific antigens) in a single production run. Despite variability in cell compositions collected from various patients, the product consistently met the purity and viability criteria reviewed by the U.S. Food and Drug Administration. The final manufacturing process is not expected to require significant changes prior to eventual commercialization.
“These manufacturing data demonstrate the robustness of our proprietary, innovative method for manufacturing ICT-107, reinforcing our consistent and controlled ability to produce vaccine for our ongoing Phase II study,” commented Manish Singh, Ph.D., IMUC’s president and CEO.
“In addition, our ability to manufacture in a single run up to 30 doses of vaccine — a multi-year supply — points to meaningful cost advantages over standard methods for producing DC vaccines,” he added, noting that the process for manufacturing Provenge, Dendreon’s DC-based vaccine for the treatment of prostate cancer, requires multiple production runs for making three shots of vaccines required for treatment as the product may not be preserved for future use, resulting in significant costs in terms of time, labor, shipping and administration.
“Based on the benefits our manufacturing process provides in terms of efficiency, cost and convenience for both patient and physician, we are confident in our ability not only to produce sufficient vaccine for current and future clinical trials, but also to bring to market a commercially viable product that has been shown to provide highly significant and urgently needed improvements in survival outcomes for patients with GBM,,” he concluded.
About ImmunoCellular Therapeutics, Ltd.
ImmunoCellular Therapeutics, Ltd.
Source: ImmunoCellular Therapeutics, Ltd.